哈佛大学陈轶文博士学术报告

     哈佛大学Dana-Farber癌症研究所陈轶文博士受哈工大生物信息学实验室(http://bioinformatics.hit.edu.cn)邀请，来太阳成官网进行学术交流，欢迎感兴趣的老师及同学参加！

 

报告题目:Surfing in the "big data" era for biological discovery: from transcription regulation to long non-coding RNA function

时        间:2014年9月19日(周五) 上午9:30

地        点:科学园2E栋411报告厅

 

Abstract:The advancement in high-throughput technologies such as microarray, next-generation sequencing (NGS) has greatly facilitated the cost-effective large-scale data generation. As a result, we are getting into the “Big Data” era of biomedical research. Despite the great opportunities in the "Big Data" era, it remains challenging to interpret and integrate different types of omic datasets for data-driven discovery in biology. In this talk, I will present several case studies of utilizing integrative approaches for biological discovery, ranging from improving the discovery of transcription factor binding sites to decoding the long non-coding RNA function in human cancer.

报告人简介：陈轶文博士2007年在美国北卡大学获得博士学位，随后在哈佛医学院进行博士后研究，2015年1月将在德州大学 M. D. Anderson Cancer Center任Assistant Professor。陈博士主要利用生物信息学的方法来阐明长链非编码RNA与人类癌症的关系，在Nature、 Nat Method、Genome Biol、 Cancer cell 、 PNAS等国际著名期刊发表多篇研究论文，代表性论文有：

1.     Chen Y#, Negre N# (# co-first author), Mieczkowska JO, Li QH, Zhang Y, He H, Kim TK, Zieba J, Ruan Y, Bickel PJ, Myers RM, Wold BJ, White KP, Lieb JD, Liu XS, Systematic evaluation of factors influencing ChIP-seq fidelity using ultra-deep sequencing. Nature Methods (2012), 9(6):609-14

2.     Du Z#, Fei T#, Verhaak RG, Su Z, Zhang Y, Brown M*, Chen Y#*(co-corresponding & co-first author), Liu XS*, Integrative genomic analyses reveal clinically relevant long non-coding RNA in human cancer. Nature Structural & Molecular Biology (2013), 20(7):908-13

3.     Chen Y, Meyer CA, Liu T, Li W, Liu JS, Liu XS, MM-ChIP enables integrative analysis of crossplatform and between-laboratory ChIP-chip or ChIP-seq data. Genome Biology (2011), 12(2):R11

4.     Ni M#, Chen Y# (# co-first author), Lim E, Wimberly H, Bailey, ST, Imai Y, Rimm DL, Liu XS, Brown M, Targeting androgen receptor in estrogen receptor-negative breast cancer. Cancer Cell (2011), 20(1)

5.     Lu T, Aron L, Zullo J, Kim H, Chen Y, Yang E, Pan Y, Drake D, Liu XS, Bennett D, Colaiacovo M, Yankner, BA, REST and stress resistance in aging and Alzheimer disease. Nature (2014), 507(7493):448-54

6.     Chen X, Iliopoulos D, Zhang Q, Tang Q, Greenblatt MB, Hatziapostolou M, Lim E, Tam W, Ni M, Chen Y, Mai J, Shen H, Hu DZ, Adoro Z, Hu B, Song M, Landis MD, Ferrari M, Brown M, Chang JC, Liu XS, Glimcher LH, XBP1 sustains tumor initiating cells in triple negative breast cancer by controlling the hypoxia response. Nature (2014), 508(7494):103-7

7.     Hsieh CL, Fei T, Chen Y, Li T, Gao Y, Wang X, Sun T, Sweeney CJ, Lee GS, Chen S, Balk SP, Liu XS, Brown M, Kantoff PW, Enhancer RNAs participate in androgen receptor-driven looping that selectively enhances gene activation. PNAS (2014), 111(20):7319-24

8.     Ni M, Chen Y, Lim E, Liu, XS, Brown M, Amplitude Modulation of Androgen Signaling by c-MYC Gene & Development (2013), 27(7):734-48

9.     Tang Q, Chen Y, Meyer CA, Geistlinger T, Lupien M, Wang Q, Liu T, Zhang Y, Brown M, Liu XS, A comprehensive view of nuclear receptor cancer cistromes. Cancer Research (2011), 71(22): 6940-7

10.  Liu T, Ortiz JA, Len Taing, Meyer CA, Lee B, Zhang Y, Shin H, Wong SS, Ma J, Lei Y, Page UJ, Poidinger M, Chen Y, Yeung K, Brown M, Turpaz Y, Liu XS, Cistrome: an integrative platform for transcriptional regulation studies. Genome Biology (2011), 12:R83