应太阳成官网生命学院蒋庆华教授邀请,美国贝勒医学院张笑天博士将于2016年11月3日来太阳成官网进行学术交流并做学术报告,欢迎感兴趣的师生参加。
题目:Co-operation of DNA Methylation Regulators inLeukemogenesis
时间:2016年11月3日(周四) 上午10:00
地点:科学园2E栋411报告厅
报告人简介:
张笑天博士2010年本科毕业于复旦大学,2016年博士毕业于美国贝勒医学院。随后,在美国贝勒医学院Margaret Goodell实验室从事博士后研究。将从2017年1月起,赴任美国VAN ANDEL Institute独立fellow并建立独立实验室。张笑天博士的研究兴趣包括DNA甲基化调控因子及染色质高级结构在白血病发生中的作用。已在Nature Genetics、Nature、PNAS、Cancer Cell、Cell Stem Cell等国际知名刊物发表10余篇科研论文,代表性论文有:
1.Zhang X, Su J, Jeong M, Ko M, Huang Y, Park H, Rao A, Li W, Goodell MA. Dnmt3a and Tet2 interact to repress lineage specific transcriptional factors in hematopoietic stem cells. Nature Genetics, 2016 Sep;48(9):1014-23. 2.
2.Karlstaedt A, Zhang X, Vasquez H, Wang J, Goodell MA, Taegtmeyer H. D-2 hydroxyglutaric acid impairs oxidative decarboxylation by α-ketoglutarate dehydrogenase in rodent heart. Proc Natl AcadSci U S A, 2016 Aug 31. pii: 201601650.
3.Yang L, Rodriguez B, Mayle A, Park HJ, Lin X, Luo M, Jeong M, Curry CV, Kim SB, Ruau D, Zhang X, Zhou T, Zhou M, Rebel VI, Challen GA, Göttgens B, Lee JS, Rau R, Li W, Goodell MA.Cancer Cell. 2016 Jun 13;29(6):922-34.
4.Luo M, Jeong M, Sun D, Park HJ, Rodriguez BA, Xia Z, Yang L, Zhang X, Sheng K, Darlington GJ, Li W, Goodell MA. Long non-coding RNAs control hematopoietic stem cell function. Cell Stem Cell. 2015 Apr 2;16(4):426-38.
5.Jeong M, Sun D, Luo M, Huang Y, Challen GA, Rodriguez B, Zhang X, Chavez L, Wang H, Hannah R, Kim SB, Yang L, Ko M, Chen R, Göttgens B, Lee JS, Gunaratne P, Godley LA, Darlington GJ, Rao A, Li W, Goodell MA. Large conserved domains of low DNA methylation maintained by Dnmt3a. Nature Genetics. 2014 Jan; 46(1):17-23.
6.Chen X, Cui D, Papusha A, Zhang X, Chu C-D, Tang J, Chen K, Pan X, Ira G (2012). The Fun30 nucleosome remodeler promotes resection of DNA double-strand break ends. Nature, 2012 Sep 27;489(7417):576-80.
7.Wang H, Wu W, Wang HW, Wang S, Chen Y, Zhang X, Yang J, Zhao S, Ding HF, Lu D. Analysis of specialized DNA polymerases expression in human gliomas: association with prognostic significance. Neuro Oncol. 2010 Jul;12(7):679-86